F4+ ETEC infection and oral immunization with F4 fimbriae elicits an IL-17-dominated immune response
نویسندگان
چکیده
منابع مشابه
F4+ ETEC infection and oral immunization with F4 fimbriae elicits an IL-17-dominated immune response
Enterotoxigenic Escherichia coli (ETEC) are an important cause of post-weaning diarrhea (PWD) in piglets. Porcine-specific ETEC strains possess different fimbrial subtypes of which F4 fimbriae are the most frequently associated with ETEC-induced diarrhea in piglets. These F4 fimbriae are potent oral immunogens that induce protective F4-specific IgA antibody secreting cells at intestinal tissues...
متن کاملMaternal immunity enhances systemic recall immune responses upon oral immunization of piglets with F4 fimbriae
F4 enterotoxigenic Escherichia coli (ETEC) cause diarrhoea and mortality in piglets leading to severe economic losses. Oral immunization of piglets with F4 fimbriae induces a protective intestinal immune response evidenced by an F4-specific serum and intestinal IgA response. However, successful oral immunization of pigs with F4 fimbriae in the presence of maternal immunity has not been demonstr...
متن کاملCholera toxin improves the F4(K88)-specific immune response following oral immunization of pigs with recombinant FaeG.
Oral immunization of both humans and animals with non-replicating soluble antigens often results in the induction of oral tolerance. However, receptor-dependent uptake of orally administered soluble antigens can lead to the induction of an antigen-specific immune response. Indeed, oral immunization of pigs with recombinant FaeG (rFaeG), the adhesin of the F4(K88) fimbriae of enterotoxigenic Esc...
متن کاملThe polymeric stability of the Escherichia coli F4 (K88) fimbriae enhances its mucosal immunogenicity following oral immunization.
Only a few vaccines are commercially available against intestinal infections since the induction of a protective intestinal immune response is difficult to achieve. For instance, oral administration of most proteins results in oral tolerance instead of an antigen-specific immune response. We have shown before that as a result of oral immunization of piglets with F4 fimbriae purified from pathog...
متن کاملScreening of pigs resistant to F4 enterotoxigenic Escherichia coli (ETEC) infection.
The present study analysed quantitatively the mucin 4 polymorphism for determining the F4ac/ab receptor status of a total of 63 pigs by comparing it with the in vitro villous adhesion assay. The probability of a susceptible genotype for the mucin 4 increases significantly with increasing F4ab or F4ac ETEC adhesion per 250 microm villi (P=0.029 for F4ab, P=0.030 for F4ac), with the odds ratio fo...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2015
ISSN: 1297-9716
DOI: 10.1186/s13567-015-0264-2